Songs from the shows will raise money for the Callum Ingham appeal on Saturday.
Children who attend the Dragons Den indoor playground in Keighley will perform songs from musicals.
Staff at the Dalton Lane centre will also take to the stage during the 8pm show.
Proceeds will support eight-year-old Callum, from Parkwood Rise in Keighley, who has an aggressive form of childhood cancer that may need costly treatment abroad.
Dragons Den staff and children recently performed an evening of West End songs and dances to raise money for Martin House children’s hospice.
Saturday’s performance will be at Haworth Methodist Church.
Call (01535) 661135 or 07455 317268 for tickets, or pop into Dragons Den.